Sodium Hydroxide → HCID 70647861, compound

Participants

Reaction Steps

Into a 50-mL recovery flask (eggplant flask), 380 mg (0.84 mmol) of methyl 6-[(4-benzhydryloxypiperidin-1-yl)difluoromethyl]pyridine-2-carboxylate synthesized in Production Example 51 was fed and dissolved in 10 mL of ethanol. Thereto, 1.7 mL of a 1-N sodium hydroxide aqueous solution was added, and the reaction was conducted at a room temperature. After the completion of the reaction was confirmed, the contents in the system were concentrated, and the residue was diluted with water. The diluted residue was neutralized with 1-N hydrochloric acid and then extracted with chloroform. The organic layer was washed with water and a saturated saline solution in order and then dried over sodium sulfate. After the solvent was concentrated, the resulting brown oily substance was purified by column chromatography (chloroform/methanol (volume ratio)=3:1) to give the title compound (306 mg (83%)).

Provenance & Evidence