反应详情

A mixture of 8.144 g of (R)-3-benzhydryloxypyrrolidine synthesized in Production Example 168, 7.701 g of a known compound ethyl 6-chloromethylpyridine-2-carboxylate, 69 mL of acetonitrile, and 9.0 mL of triethylamine was heated under reflux for 3 hours. After being allowed to cool down, the mixture was diluted with ethyl acetate. The diluted mixture was poured into a saturated saline solution, and the organic layer was collected by separation. The organic layer was washed with a saturated saline solution and dried over magnesium sulfate. The solvent was distilled off, and then the residue was purified by silica gel column chromatography (chloroform/acetone (volume ratio)=15:1 to 10:1) to give the title compound (7.22 g (54%)).

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. temperatureto cool down
4. additionThe diluted mixture was poured into a saturated saline solution
5. customthe organic layer was collected by separation
6. washThe organic layer was washed with a saturated saline solution
7. dry with materialdried over magnesium sulfate
8. distillationThe solvent was distilled off
9. customthe residue was purified by silica gel column chromatography (chloroform/acetone (volume ratio)=15:1 to 10:1)