HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Difluoroacetic acid | HCID 9788 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-Imino-3-(3-trifluoromethyl-phenyl)-5-methylthiazoline hydrochloride | HCID 21480071 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline | HCID 11088983 | 62.6% |
Reaction Steps
A mixture of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline hydrochloride (0.42 g), triethylamine (2.2 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.8 g) and difluoroacetic acid (0.75 g) in chloroform (10 ml) was refluxed for 8 hours. The residue was washed with aqueous hydrochloric acid and aqueous potassium carbonate and dried over magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 2-difluoroacetylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound No. 63) (0.3 g). m.p., 117.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05426188 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-840ef424ea6848aab829e8871146298a |
| Source note | uspto-grants-1995_06 |