Pivaloyl chloride → 2,2-Dimethyl-N-(3-oxo-propyl)-propionamide

HRID 220260Notes

Reaction equation

CC(C)(C)C(Cl)=O.CO[CH2:10][C:11]([CH2:20]OC)([CH3:19])[C:12]([NH:14][CH2:15][CH2:16][CH:17]=[O:18])=[O:13]>>[CH3:10][C:11]([CH3:20])([CH3:19])[C:12]([NH:14][CH2:15][CH2:16][CH:17]=[O:18])=[O:13]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 866419283-methoxy-2-methoxymethyl-2-methyl-N-(3-oxo-propyl)-propionamide

Product 1

HCID 202736192,2-Dimethyl-N-(3-oxo-propyl)-propionamide

Procedure

Prepared from 2,2-dimethyl-propionyl chloride in absence of a coupling reagent in analogy to the methods described for 3-methoxy-2-methoxymethyl-2-methyl-N-(3-oxo-propyl)-propionamide.

Sources & evidence

ORD record: ord-822d32eae0de476cb3b0371599b82223
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202885B2

Reaction notes

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