Hydrazine hydrate (1:1) → HCID 178503599, compound

Participants

Reaction Steps

To a solution of 2-(bis(methylthio)methylene)malononitrile (5.0 g, 29.37 mmol) in EtOH (20 mL) was added a solution of hydrazine hydrate (64% solution in water) (1.469 g, 45.82 mmol) in EtOH (10 mL) dropwise with stirring. The reaction mixture was stirred at room temperature for 1 hr and then at 70° C. overnight. After the reaction mixture was concentrated, the solid residual was trituated with EtOAc and hexanes. The resulting solid was filtered and dried to give compound I-12 (3.243 g, 71.7% yield, 94.7% purity) as a white powder.

Provenance & Evidence