HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzaldehyde → HCID 178510299, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzaldehyde | HCID 67996 | — |
| Reactant | 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole | HCID 10681167 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178510299 | HCID 178510299 | 42% |
Reaction Steps
5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile (100 mg) was suspended in EtOH (4 mL) and alpha,alpha,alpha-Trifluoro-p-tolualdehyde (1 eq.) and piperidine (1 drop) were added. Stirred at reflux until intermediate was absent (HPLC). After reaction was complete (18 hrs) it was brought to room temperature and filtered to obtain A15 as a yellow powder. Powder was washed with EtOH. Product was allowed to dry under vacuum for 1 hr (71 mg, 42% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365556B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-12251530e15048df915bd75aab3374c5 |
| Source note | uspto-grants-2016_06 |