HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-4H-1,3-benzodioxine-8-carbaldehyde → HCID 178510304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-4H-1,3-benzodioxine-8-carbaldehyde | HCID 2779905 | — |
| Reactant | 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole | HCID 10681167 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178510304 | HCID 178510304 | 60% |
Reaction Steps
5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile (100 mg) was then suspended in EtOH (4 mL) and 6-fluoro-4H-1,3-benzodioxine-8-carbaldehyde (1 eq.) and piperidine (1 drop) were added. Stirred at reflux until intermediate was absent (HPLC). After reaction was complete (18 hrs) it was brought to room temperature and filtered to obtain A29 as a yellow powder. Powder was washed with EtOH. Product was allowed to dry under vacuum for 1 hr (103 mg, 60% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365556B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-23ed46cd2d474682a96647c674a8924a |
| Source note | uspto-grants-2016_06 |