Methyl iodide → HCID 7718564, compound

Participants

Reaction Steps

Dissolved malononitrile (5.0 g) in DMF (50 mL), added triethylamine (1 eq), and stirred for 5 minutes before adding 4-nitrophenyl isothiocyanate (1 eq) dropwise, then stirred until complete by TLC (absence of 4-Nitrophenyl isothiocyanate, 3 hrs). Added methyl iodide (1 eq) dropwise, then stirred until intermediate was fully consumed (absent on TLC, 18 hrs); poured into 500 mL ice water, then filtered resulting solution to obtain 2-((methylthio)((4-nitrophenyl)amino)methylene)malononitrile as a white powder.

Provenance & Evidence