HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Difluoromethoxy)-3-hydroxybenzaldehyde → HCID 136218058, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | HCID 2758295 | — |
| Reactant | 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide | HCID 86698956 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 136218058 | HCID 136218058 | — |
Reaction Steps
5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carboxamide was then suspended in EtOH and 4-(difluoromethoxy)-3-hydroxybenzaldehyde (1 eq.) and piperidine (1 drop) were added. Stirred at reflux until intermediate was absent (HPLC). After reaction was complete (18 hrs) it was brought to room temperature and filtered to obtain product as a yellow powder. Powder was washed with EtOH. Product was allowed to dry under vacuum for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365556B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f9186d9c420348f688bdff8c2a7ef999 |
| Source note | uspto-grants-2016_06 |