反应详情

温度

0 °C

To a stirred solution of compound A103-1 (164 mg, 0.832 mmol) in DCM (2 mL) was added diisobutylaluminum hydride (1 M in hexane, 1.0 mL, 1.0 mmol) at −78° C. under nitrogen atmosphere. After 0.5 h, the mixture was allowed to warm to 0° C. and stirred for 0.5 h. The reaction mixture was quenched with sat. KHSO4 aq. (10 mL) and extracted with DCM (2×4 mL). The combined organic layers were directly used in the next step without further purification.

1. customThe reaction mixture was quenched with sat. KHSO4 aq. (10 mL)
2. extractionextracted with DCM (2×4 mL)
3. customThe combined organic layers were directly used in the next step without further purification