Sodium Methoxide → HCID 53662628, compound

HRID 22027Notes

Reaction equation

HRID 22027 reaction equation
[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH:10]=[C:9]([CH3:22])[S:8]1)=[O:5])C.C[O-].[Na+]>CO>[CH3:1][O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=2)[CH:10]=[C:9]([CH3:22])[S:8]1)=[O:5]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 538034182-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl) 5-methylthiazoline

Product 1

HCID 53662628HCID 53662628, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-ethoxycarbonylimino-3-(3-tri-fluoromethylphenyl)-5-methylthiazoline (1.0 g) and sodium methoxide (28% methanolic solution; 0.6 g) in methanol (30 ml) was refluxed for 10 hours. After removal of the solvent, the residue was extracted with chloroform (100 ml), washed with water and dried over anhydrous magnesium. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.8 g of 2-methoxycarbonylimino-3- (3-trifluoromethylphenyl) 5-methylthiazoline (Compound No. 3).

Workup

  1. customAfter removal of the solvent
  2. extractionthe residue was extracted with chloroform (100 ml)
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium
  5. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-44637d2bb44c47c996453a2d0a3af34c
Source dataset
uspto-grants-1995_06
Patent number
US05426188

Reaction notes

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