反应详情

3-Trifluoromethoxy-benzene-1,2-diamine was synthesized by dissolving 0.79 g of 2-nitro-6-trifluoromethoxy-phenylamine (J. Med. Chem. 1999, 42, 15, 2828-2843) in 20 mL EtOH, evacuating 3 times with N2 and adding 80 mg of 10 wt % Pd/C. The reaction mixture was stirred under a H2 atmosphere (balloon) for 5 h. Filtration over a pad of celite and washing with EtOH and EtOAc yielded after concentration in vacuo 0.55 g of 3-trifluoromethoxy-benzene-1,2-diamine as brown oil.

1. customevacuating 3 times with N2
2. additionadding 80 mg of 10 wt % Pd/C
3. filtrationFiltration over a pad of celite
4. washwashing with EtOH and EtOAc
5. customyielded
6. concentrationafter concentration in vacuo 0.55 g of 3-trifluoromethoxy-benzene-1,2-diamine as brown oil