Benzyl Alcohol → Benzyl 4,4,4-trifluoroacetoacetate

HRID 2202720Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202720
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].C(O)[C:14]1[CH:19]=[CH:18]C=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[F:1][C:2]([F:11])([F:12])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:18]=[CH:19][CH:14]=[CH:15][CH:16]=1)=[O:6]

Komponenten

4

Edukt 2

HCID 244Benzyl AlcoholHCID 67793Ethyl 4,4,4-trifluoroacetoacetate

Produkt 1

HCID 13136519Benzyl 4,4,4-trifluoroacetoacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a solution of ethyl 4,4,4-trifluoro-3-oxobutanoate (17.0 g, 92.3 mmol) in toluene (80 mL) was added benzylalcohol (11.4 mL, 109.6 mmol). The mixture was stirred at 120° C. by using Dean-Stark for 5 h, and then the reaction mixture was cooled to 0° C. Drying the solution under high vacuum yielded compound D1-3 (21.2 g, quant.) as a colorless oil, which was used to the next step without further purification.

Aufarbeitung

  1. customfor 5 h
  2. temperaturethe reaction mixture was cooled to 0° C
  3. customDrying the solution under high vacuum
  4. customyielded compound D1-3 (21.2 g, quant.) as a colorless oil, which
  5. customwas used to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-543916dab8b749749e3238353737979d
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365522B2

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