3,6-Dimethoxybenzene-1,2-diamine → [3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)propyl]methylamine

HRID 220275Notes

Reaction equation

HRID 220275 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([NH2:11])[C:4]=1[NH2:12].CO[C:15]1C(OC)=C[C:18]2[NH:19][C:20](CCCNC)=N[C:17]=2[CH:16]=1>>[CH3:10][O:9][C:6]1[C:5]2[N:11]=[C:15]([CH2:16][CH2:17][CH2:18][NH:19][CH3:20])[NH:12][C:4]=2[C:3]([O:2][CH3:1])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 116296603,6-Dimethoxybenzene-1,2-diamineHCID 61363740[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine

Product 1

HCID 66876408[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)propyl]methylamine

Procedure

Prepared from 3,6-dimethoxy-benzene-1,2-diamine in analogy to the methods described for [3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

Sources & evidence

ORD record
ord-2878aae0f8a2434d9f83c46beb0801eb
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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