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HRID220281

反应详情

EQUATION

反应方程式

HRID 220281 的结构方程式

REACTANTS

反应物

1
结构：CN(CCCC(=O)Nc1cccc([N+](=O)[O-])c1N)C(=O)OC(C)(C)C
HCID68412474

未命名化合物

PRODUCTS

生成物

1
结构：CN(CCCc1nc2c([N+](=O)[O-])cccc2[nH]1)C(=O)OC(C)(C)C
HCID68412537

未命名化合物

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A solution of 4.4 g of [3-(2-amino-3-nitro-phenylcarbamoyl)-propyl]methyl-carbamic acid tert-butyl ester in 36 mL of acetic acid was heated at 90° C. for 5 h and concentrated in vacuo. The residue was taken up in DCM, washed with sat. NaHCO3 solution, dried over anh. Na2SO4 and concentrated in vacuo to yield 3.8 g of methyl-[3-(4-nitro-1H-benzoimidazol-2-yl)-propyl]-carbamic acid tert-butyl ester as dark yellow oil.

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. washwashed with sat. NaHCO3 solution
  3. dry with materialdried over anh. Na2SO4
  4. concentrationconcentrated in vacuo