HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide | HCID 21772024 | 86.2% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 ml) was heated at 100° C. overnight. The mixture was poured into water (1.2 L) with stirring, and the resulting precipitate was collected by filtration. The solid was washed with water and Et2O successively, and dried in vacuo to give the title compound (37.4 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365540B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-422f574d8bea46a58baca58f1cde2d9c |
| Source note | uspto-grants-2016_06 |