HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202849Generated: October 29, 2026
Ammonia → 4-((4-Fluorobenzyl)oxy)-1-(3-(methylamino)-4-nitrophenyl)pyridin-2(1H)-one
https://huagongshe.com/reaction/2202849
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-bromo-N-methyl-2-nitroaniline | HCID 10609530 | — |
| Reactant | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-((4-Fluorobenzyl)oxy)-1-(3-(methylamino)-4-nitrophenyl)pyridin-2(1H)-one | HCID 89690442 | 75.8% |
Reaction Steps
A mixture of 4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (2.06 g), 5-bromo-N-methyl-2-nitroaniline (2.17 g), N,N′-dimethylethylenediamine (1.00 ml), copper iodide (1.79 g), potassium carbonate (3.90 g) and DMSO (30 ml) was stirred at 150° C. for 2 h. The mixture was added to 28% NH3 solution. The precipitate was collected and washed with water to give the title compound (2.63 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-fce879045d814c4d8f7b304d8cfffe5a |
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| Source note | uspto-grants-2016_06 |
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