Hydrochloric Acid → HCID 68415350, compound

Participants

Reaction Steps

A solution of 6.25 g of a mixture of N-(6-chloro-3-methoxy-2-nitro-phenyl)-acetamide and N-(2-chloro-5-methoxy-4-nitro-phenyl)-acetamide in 30 mL of 25%-HCl and 150 mL of 1M-HCl was refluxed for 2 h. The reaction mixture was basified with 2M-NaOH and extracted with EtOAc. The organic phase was dried over anh. Na2SO4 and concentrated in vacuo. The crude product was purified by CC using EtOAc/heptane 1/3 to yield 819 mg of 6-chloro-3-methoxy-2-nitro-phenylamine as dark yellow oil.

Provenance & Evidence