HCID 121386223, compound → HCID 89691048, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(5-bromo-2-nitrophenyl)-N,3,3-trimethylbutanamide (300 mg) in AcOH (5 ml) was added zinc (596 mg) at room temperature. Then the mixture was heated at 90° C. for 2 h. The inorganic material was removed by filtration, and the filtrate was concentrated. The residue was poured into a mixture of EtOAc and saturated NaHCO3 solution. The organic layer was washed with brine, dried over MgSO4, concentrated, and purified by NH silica gel column chromatography (hexane/EtOAc) to give the title compound (200 mg) as a white solid.

Provenance & Evidence