N,N'-Dimethylethylenediamine → HCID 89691349, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (78 mg), 6-bromo-2-(2,2-dimethylpropyl)-1-methyl-1H-benzimidazole (100 mg), N,N′-dimethylethylenediamine (31 mg), copper iodide (68 mg), potassium carbonate (147 mg) and DMSO (2 ml) was heated under Ar atmosphere at 150° C. for 2 h. The mixture was partitioned between 14% aqueous NH3 and EtOAc. The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by NH silica gel column chromatography (hexane/EtOAc) to give the title compound (50 mg) as a white solid.

Provenance & Evidence