HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202872Generated: October 31, 2026
N,N'-Dimethylethylenediamine → HCID 89691290, compound
https://huagongshe.com/reaction/2202872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| Reactant | HCID 121386244 | HCID 121386244 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89691290 | HCID 89691290 | 16.9% |
Reaction Steps
A mixture of 4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (236 mg), (6-bromo-1-methyl-1H-benzimidazol-2-yl)(cyclopropyl)methanone (300 mg), N,N′-dimethylethylenediamine (0.115 ml), copper iodide (205 mg) and potassium carbonate (594 mg) in DMSO (3 ml) was stirred at 150° C. for 1 h. The mixture was purified by NH silica gel column chromatography (hexane/EtOAc). The obtained solid was washed with water and IPE to give the title compound (76 mg) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365540B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-8ee2e9d6aaeb4f559229d0c73f9e7f2b |
|---|
| Source note | uspto-grants-2016_06 |
|---|
