Thionyl Chloride → HCID 119086486, compound

Participants

Reaction Steps

To a stirred solution of (6-iodo-3-methylimidazo[1,2-a]pyridin-2-yl)methanol (200 mg) in DCM (2 ml) was added thionyl chloride (56 μl) at room temperature, and the mixture was stirred for 4 h. Additional thionyl chloride (125 μl) was added to the reaction mixture, and the mixture was stirred for further 3 h. The reaction mixture was diluted with DCM, and washed with saturated NaHCO3 solution. The DCM layer was separated, dried over Na2SO4 and concentrated in vacuo to give the title compound (150 mg) as a yellow solid.

Provenance & Evidence