Water → 4-((4-Fluorobenzyl)oxy)-1-(1-methyl-2-(trichloromethyl)-1H-benzimidazol-6-yl)pyridin-2(1H)-one

Participants

Reaction Steps

To a mixture of 1-(4-amino-3-(methylamino)phenyl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (270 mg) in AcOH (3 ml) was added methyl 2,2,2-trichloroacetimidate (0.196 ml) dropwise at 0° C. The mixture was stirred at room temperature for 2 h. Water was added to the mixture. The resulting precipitate was collected by filtration and dried to give the title compound (220 mg) as an ivory solid.

Provenance & Evidence