HCID 121386246, compound → HCID 119086488, compound

Participants

Reaction Steps

A mixture of 6-iodo-3-methylimidazo[1,2-a]pyridine-2-carboxamide (600 mg) and POCl3 (40 ml) was heated at reflux for 3 h. The mixture was then cooled to room temperature, and the reaction mixture was concentrated in vacuo. The residue was poured into ice-cold saturated NaHCO3 solution, and extracted with EtOAc. The extract was washed with water and brine, dried over Na2SO4 and concentrated in vacuo to give the title compound (500 mg) as a yellow solid.

Provenance & Evidence