Acetonitrile → HCID 89690348, compound

Participants

Reaction Steps

To a mixture of 5-hydroxy-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one (200 mg), 1-bromomethyl-4-chlorobenzene (209 mg), CH3CN (8 ml) and DMF (1 ml) was added potassium carbonate (282 mg), and the resulting mixture was stirred at room temperature for 16 h. The reaction mixture was then concentrated in vacuo and diluted with water. The mixture was extracted with EtOAc, and extract was washed successively with water and brine, dried over Na2SO4 and concentrated in vacuo. The residue was triturated with n-hexane to give the title compound (210 mg) as a white solid.

Provenance & Evidence