HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202903Generated: November 1, 2026
N,N'-Dimethylethylenediamine → HCID 89691148, compound
https://huagongshe.com/reaction/2202903
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| Reactant | HCID 83866933 | HCID 83866933 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89691148 | HCID 89691148 | 9.8% |
Reaction Steps
A mixture of 4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (312 mg), 1-(6-bromo-1-methyl-1H-benzimidazol-2-yl)ethanone (360 mg), N,N′-dimethylethylenediamine (0.141 ml), copper iodide (250 mg) and potassium carbonate (393 mg) in DMSO (3 ml) was stirred at 150° C. for 1 h. The mixture was purified by NH silica gel column chromatography (hexane/EtOAc). The resulting solid was recrystallized from EtOH/IPA to give the title compound (54.6 mg) as a pale orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-0ba596123e474d0aad9868350370f8bf |
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| Source note | uspto-grants-2016_06 |
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