Pyridine → HCID 89691230, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic anhydride (0.109 ml) was added to a solution of (1RS,2RS)-2-(6-(4-((4-chlorobenzyl)oxy)-2-oxopyridin-1(2H)-yl)-1-methyl-1H-benzimidazol-2-yl)cyclopropanecarboxamide (117 mg) and pyridine (0.063 ml) in THF (3 ml) at 0° C. The mixture was stirred at 0° C. under Ar atmosphere for 1 h. The mixture was quenched with saturated NaHCO3 solution at 0° C. and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The resulting solid was crystallized from THF/hexane to give the title compound (15 mg) as an off-white solid.

Provenance & Evidence