反应详情

To a stirred mixture of 2-bromopentan-3-one (2.0 g), 2-amino-5-iodopyridine (1.0 g) and EtOH (50 ml) was heated at reflux for 16 h. The reaction mixture was cooled and concentrated in vacuo. The residue was diluted with water (100 ml), and extracted with DCM. The DCM layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (400 mg) as a yellow solid.

1. temperaturewas heated
2. temperatureat reflux for 16 h
3. temperatureThe reaction mixture was cooled
4. concentrationconcentrated in vacuo
5. additionThe residue was diluted with water (100 ml)
6. extractionextracted with DCM
7. washThe DCM layer was washed with brine
8. dry with materialdried over Na2SO4
9. concentrationconcentrated in vacuo
10. customThe residue was purified by silica gel column chromatography (hexane/EtOAc)