HCID 89690578, compound → HCID 89690567, compound

Participants

Reaction Steps

Zinc (9.49 g) was added to a solution of 4-(benzyloxy)-1-(3-(methylamino)-4-nitrophenyl)pyridin-2(1H)-one (5.1 g) in AcOH (120 ml) at room temperature. The mixture was stirred at room temperature for 2 h. The insoluble material was removed by filtration, and the filtrate was concentrated in vacuo. The mixture was neutralized with saturated NaHCO3 solution at 0° C. and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was washed with IPE and dried to give the title compound (3.5 g) as a brown solid.

Provenance & Evidence