HRID2202973

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID87190995

未命名化合物

反应SMILES：Cn1c(C2CC2C(C)(C)O)nc2ccc(-n3ccc(OCc4ccc(Cl)cc4)cc3=O)cc21

HCID89691107

未命名化合物

PRODUCTS

产物

反应SMILES：Cn1c([C@@H]2C[C@@H]2C(C)(C)O)nc2ccc(-n3ccc(OCc4ccc(Cl)cc4)cc3=O)cc21

HCID121386224

未命名化合物

收率 32.5%

PROCEDURE

实验过程

(1RS,2SR)-4-((4-Chlorobenzyl)oxy)-1-(2-(2-(2-hydroxypropan-2-yl)cyclopropyl)-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (0.830 g) was resolved by a preparative SFC (CHIRALPAK AYH, CO2/EtOH/CH3CN=600/200/200) to give a white solid (355 mg, >99% ee). This solid was recrystallized from IPA to give the title compound (270 mg) as a white solid.

WORKUP

后处理

customto give a white solid (355 mg, >99% ee)
customThis solid was recrystallized from IPA