HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202980Generated: November 1, 2026
Potassium Carbonate → HCID 89690619, compound
https://huagongshe.com/reaction/2202980
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | 4-(4-Fluorobenzyloxy)-1h-pyridin-2-one | HCID 22049900 | — |
| Reactant | HCID 70251217 | HCID 70251217 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89690619 | HCID 89690619 | 30.2% |
Reaction Steps
To a mixture of 6-iodo-2,3-dimethylimidazo[1,2-a]pyridine (204 mg), 4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one (150 mg), potassium carbonate (283 mg) and dioxane (15 ml) were added CuI (51 mg) and trans-N,N′-dimethyl-cyclohexane-1,2-diamine (38 mg), and the mixture was heated at 110° C. in a sealed tube for 16 h. The reaction mixture was then cooled to room temperature, and concentrated in vacuo. The residue was diluted with DCM, washed with brine, dried over Na2SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (MeOH/DCM) to afford the title compound (75 mg) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365540B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-91d9d94eaead4dc4922e7f2b4d39f089 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
