HCID 121386212, compound → HCID 89691109, compound

Participants

Reaction Steps

To a stirred solution of ethyl 2-(6-(4-((4-chlorobenzyl)oxy)-2-oxopyridin-1(2H)-yl)-3-methylimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxylate (250 mg) in THF (2 ml) was added methylmagnesium bromide (3.0 M solution in ether, 1.8 ml) at 0° C., and the resulting mixture was stirred at room temperature for 3 h. The reaction mixture was then quenched with saturated NH4Cl solution, and extracted with DCM. The extract was washed with brine, dried over Na2SO4, concentrated in vacuo and purified by column chromatography (MeOH/DCM) to afford the title compound (7 mg) as an off-white solid.

Provenance & Evidence