反应详情

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline (0.5 g) and N-iodosuccinimide (0.4 g) in chloroform (30 ml) was refluxed for 20 hours. After cooling, the reaction mixture was washed with an aqueous sodium sulfite solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.1 g of 2-ethoxycarbonylimino-3-(3-tri-fluoromethylphenyl)-5-iodothiazoline (Compound No. 42).

1. temperatureAfter cooling
2. washthe reaction mixture was washed with an aqueous sodium sulfite solution
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed under reduced pressure