HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203000Generated: October 29, 2026
Potassium Carbonate → HCID 89702554, compound
https://huagongshe.com/reaction/2203000
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | 4-[(4-Chlorophenyl)methoxy]pyridin-2(1H)-one | HCID 57497864 | — |
| Reactant | HCID 89690441 | HCID 89690441 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89702554 | HCID 89702554 | 43.3% |
Reaction Steps
To a mixture of 2-(6-iodo-3-methylimidazo[1,2-a]pyridin-2-yl)cyclopropanecarbonitrile (26 mg), 4-((4-chlorobenzyl)oxy)pyridin-2(1H)-one (45 mg), potassium carbonate (58 mg) and dioxane (2 ml) were added CuI (7 mg) and trans-N,N′-dimethyl-cyclohexane-1,2-diamine (5 mg), and the mixture was heated at 110° C. for 16 h. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The residue was diluted with DCM, washed with brine, dried over Na2SO4, concentrated in vacuo and purified by column chromatography (MeOH/DCM) to afford the title compound (15 mg) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-7cccec4e6a484ce69558712e5b2544bc |
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| Source note | uspto-grants-2016_06 |
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