反应详情

温度

120 °C

A mixture of 4-bromo-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one (285 mg), (5-fluorothiophen-2-yl)methanol (109 mg), potassium tert-butoxide (93 mg) and DME (5 ml) was heated at 120° C. for 30 min under microwave irradiation. Additional potassium tert-butoxide (93 mg) and (5-fluorothiophen-2-yl)methanol (109 mg) in DME (0.5 ml) were added to the reaction mixture, and the resulting mixture was heated at 120° C. for further 30 min under microwave irradiation. The mixture was quenched with water and extracted with EtOAc/MeOH. The organic layer was separated, washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was crystallized from EtOH-IPA to give the title compound (120 mg) as an off-white solid.

1. temperaturethe resulting mixture was heated at 120° C. for further 30 min under microwave irradiation
2. customThe mixture was quenched with water
3. extractionextracted with EtOAc/MeOH
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo
8. customThe residue was crystallized from EtOH-IPA