反应详情

温度

100 °C

A mixture of 4-bromo-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one (100 mg), (5-(difluoromethyl)-3-thienyl)methanol (88 mg), potassium tert-butoxide (109 mg) and toluene (3 ml) was heated at 100° C. for 1 h. The reaction mixture was then cooled to room temperature, poured into water and extracted with EtOAc-THF. The extract was washed with brine, dried over MgSO4, concentrated and purified by NH silica gel column chromatography (hexane/EtOAc). The resulting solid was recrystallized from IPA-IPE to give the title compound (64.1 mg) as a white solid.

1. temperatureThe reaction mixture was then cooled to room temperature
2. extractionextracted with EtOAc-THF
3. washThe extract was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. custompurified by NH silica gel column chromatography (hexane/EtOAc)
7. customThe resulting solid was recrystallized from IPA-IPE