Tetrahydrofuran → HCID 89702430, compound

Participants

Reaction Steps

Ethylmagnesium bromide (1.0 M solution in THF, 1.29 ml) was added to a solution of methyl(1RS,2RS)-2-(6-(4-((4-chlorobenzyl)oxy)-2-oxopyridin-1(2H)-yl)-1-methyl-1H-benzimidazol-2-yl)cyclopropanecarboxylate (150 mg) in THF (5 ml) at 0° C., and the mixture was stirred at room temperature for 3 h. The mixture was quenched with saturated NH4Cl solution, and extracted with EtOAc. The organic layer was separated, washed with water and brine successively, dried over MgSO4, and concentrated in vacuo. The residue was purified by NH silica gel column chromatography (EtOAc/MeOH), and the resulting solid was crystallized from EtOH to give the title compound (48 mg) as a white solid.

Provenance & Evidence