HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203036Generated: October 31, 2026
N,N'-Dimethylethylenediamine → HCID 89702445, compound
https://huagongshe.com/reaction/2203036
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-[(4-Chlorophenyl)methoxy]pyridin-2(1H)-one | HCID 57497864 | — |
| Reactant | HCID 89691245 | HCID 89691245 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89702445 | HCID 89702445 | 3.4% |
Reaction Steps
A mixture of 4-((4-chlorobenzyl)oxy)pyridin-2(1H)-one (100 mg), 1-(6-bromo-1-methyl-1H-benzo[d]imidazol-2-yl)propan-1-one (170 mg), N,N′-dimethylethylenediamine (0.046 ml), CuI (81 mg) and potassium carbonate (176 mg) in DMSO (3 ml) was stirred at 150° C. for 30 min under N2 atmosphere. The mixture was purified by NH silica gel column chromatography (hexane/EtOAc), followed by recrystallization from IPA to give the title compound (6.1 mg) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-fd6ddb1e180e4bb1a482bbb6aaa6008e |
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| Source note | uspto-grants-2016_06 |
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