Acetic Acid → HCID 89691123, compound

Participants

Reaction Steps

To a stirred solution of N-(2-amino-4-bromophenyl)-3-oxocyclobutanecarboxamide (2.7 g) in CH3CN (20 ml) was added AcOH (2 ml), and the mixture was heated under reflux for 3 h. The mixture was concentrated in vacuo, and poured into saturated NaHCO3 solution. The mixture was extracted with EtOAc, washed with water and brine successively, dried over Na2SO4, concentrated in vacuo, and purified by column chromatography (hexane/EtOAc) to afford the title compound (2.0 g) as an off-white solid.

Provenance & Evidence