Phosphorus oxychloride → HCID 89690996, compound

Participants

Reaction Steps

To a stirred solution of 1-(3-(6-bromo-1-methyl-1H-benzimidazol-2-yl)cyclobutyl)-N-hydroxymethanimine (100 mg) in CH3CN (10 ml) was added phosphorous oxychloride (1 ml), and the mixture was stirred at room temperature for 16 h. The mixture was then concentrated in vacuo and poured into saturated NaHCO3 solution. The mixture was extracted with DCM, and the organic layer was washed with brine, dried over Na2SO4 and purified by column chromatography (MeOH/DCM) to afford the title compound (50 mg) as a yellow solid.

Provenance & Evidence