HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203096Generated: November 1, 2026
Bromopyruvic Acid → 2-(Ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid
https://huagongshe.com/reaction/2203096
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromopyruvic Acid | HCID 70684 | — |
| Reactant | Ethyl thiooxamate | HCID 2733398 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid | HCID 53487863 | 48.5% |
Reaction Steps
A mixture of ethyl 2-amino-2-thioxoacetate (10.1 g), 3-bromo-2-oxopropanoic acid (12.7 g) and THF (200 ml) was stirred at 50° C. overnight. The mixture was concentrated in vacuo, and the resulting solid was suspended in EtOAc. The precipitate was collected by filtration to give the title compound (7.4 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-a66a0c4a3d2a46ff8b51d706f7b576c5 |
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| Source note | uspto-grants-2016_06 |
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