Triphenylphosphine → HCID 89691175, compound

Participants

Reaction Steps

To a suspension of 1-(2-cyclopropyl-1-methyl-1H-benzo[d]imidazol-6-yl)-4-hydroxypyridin-2(1H)-one (100 mg), (4-(fluoromethyl)thiazol-2-yl)methanol (105 mg), triphenylphosphine (280 mg) and THF (5 ml) was added bis(2-methoxyethyl) azodicarboxylate (250 mg), and the mixture was stirred at room temperature for 2 h, then at 70° C. for 2 h. The mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated in vacuo, and purified by silica gel column chromatography (EtOAc/MeOH) to give the title compound (4.0 mg) as a white solid.

Provenance & Evidence