Tetrahydrofuran → HCID 20086718, compound

Participants

Reaction Steps

A mixture of 2,2,3,3,3-pentafluoropropanamide (2 g), Lawesson's reagent (2.98 g) and THF (30 ml) was heated under reflux overnight. Then ethyl 3-bromo-2-oxopropanoate (2.99 g) was added, and the mixture was heated at the same temperature overnight. The mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (0.91 g) as a yellow solid.

Provenance & Evidence