HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 2-Thiazolemethanol, 4-(difluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Ethyl 4-(difluoromethyl)-1,3-thiazole-2-carboxylate | HCID 89690429 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Thiazolemethanol, 4-(difluoromethyl)- | HCID 68096379 | 98% |
Reaction Steps
To a solution of ethyl 4-(difluoromethyl)-1,3-thiazole-2-carboxylate (900 mg) in MeOH (15 ml) was added NaBH4 (329 mg), and the mixture was stirred at room temperature for 2 h. The mixture was partitioned between saturated NH4Cl solution and EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound (703 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365540B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-cbb5073800864f14a8eaed68c6c1d4f9 |
| Source note | uspto-grants-2016_06 |