反应详情

A mixture of (S)-2-amino-hexanedioic acid (50 g, 310.25 mmol), acetic acid (100 mL), and water (400 mL) water was refluxed for 3 h. The unchanged starting amino acid was filtered off (24 g) and the filtrate evaporated, dissolved in hot water (50 mL) and then cooled. A crystalline precipitate formed which was filtered to provide the title intermediate (20 g, 45% yield).

1. temperaturewas refluxed for 3 h
2. filtrationwas filtered off (24 g)
3. customthe filtrate evaporated
4. dissolutiondissolved in hot water (50 mL)
5. temperaturecooled
6. customA crystalline precipitate formed which
7. filtrationwas filtered