Methyl 5-(trifluoromethyl)-1H-indazole-7-carboxylate → Methyl 5-(trifluoromethoxy)-1H-indazole-7-carboxylate

HRID 2203156Notes

Reaction equation

HRID 2203156 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([C:12]([O:14][CH3:15])=[O:13])[CH:11]=1)[NH:8][N:7]=[CH:6]2.NC1C(C)=CC([O:30][C:31]([F:34])([F:33])[F:32])=CC=1C(OC)=O>>[F:32][C:31]([F:34])([F:33])[O:30][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([C:12]([O:14][CH3:15])=[O:13])[CH:11]=1)[NH:8][N:7]=[CH:6]2

Participants

3

Reactant 2

HCID 118251578Methyl 5-(trifluoromethyl)-1H-indazole-7-carboxylateHCID 118251634Methyl 2-amino-3-methyl-5-(trifluoromethoxy)benzoate

Product 1

HCID 118251604Methyl 5-(trifluoromethoxy)-1H-indazole-7-carboxylate

Procedure

The title compound was prepared as in the method of compound 4 from methyl 2-amino-3-methyl-5-(trifluoromethoxy)benzoate to give an off-white solid (0.355 g, 83%).

Sources & evidence

ORD record
ord-dda23f89fcb547abae24552a0817e4c9
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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