Isobutyl iodide → HCID 118251644, compound

HRID 2203157Notes

Reaction equation

HRID 2203157 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Cl:14])[CH:8]=[C:9]2[C:13]=1[NH:12][N:11]=[CH:10]2)=[O:4].I[CH2:16][CH:17]([CH3:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Cl:14])[CH:8]=[C:9]2[C:13]=1[N:12]([CH2:16][CH:17]([CH3:19])[CH3:18])[N:11]=[CH:10]2)=[O:4]

Participants

3

Reactant 2

HCID 10556Isobutyl iodideHCID 53419723HCID 53419723, compound

Product 1

HCID 118251644HCID 118251644, compoundYield 48%

Procedure

Compound 9 was prepared following general method 1, using 5-chloro-1H-indazole-7-carboxylic acid methyl ester (see WO2011008572 which is incorporated by reference in its entirety) as starting material and 1-iodo-2-methylpropane as alkylating agent. Yield: 48%.

Sources & evidence

ORD record
ord-9783397e7eb34a619612b6ea10660439
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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