Isobutyl iodide → 1-Isobutyl-5-trifluoromethoxy-1H-indazole-7-carboxylic acid methyl ester

HRID 2203161Notes

Reaction equation

HRID 2203161 reaction equation
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:12]=1)[NH:9][N:8]=[CH:7]2.I[CH2:20][CH:21]([CH3:23])[CH3:22]>>[CH3:16][O:15][C:13]([C:11]1[CH:12]=[C:4]([O:3][C:2]([F:1])([F:17])[F:18])[CH:5]=[C:6]2[C:10]=1[N:9]([CH2:20][CH:21]([CH3:23])[CH3:22])[N:8]=[CH:7]2)=[O:14]

Participants

3

Reactant 2

HCID 10556Isobutyl iodideHCID 118251604Methyl 5-(trifluoromethoxy)-1H-indazole-7-carboxylate

Product 1

HCID 1182516111-Isobutyl-5-trifluoromethoxy-1H-indazole-7-carboxylic acid methyl esterYield 56%

Procedure

Compound 13 was prepared following general method 1, using compound 8 as starting material and 1-iodo-2-methylpropane as alkylating agent. Yield: 56%.

Sources & evidence

ORD record
ord-35d9a40f0b2b4c51b4c7db7ca385f51c
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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