Methyl 1H-indazole-5-carboxylate → HCID 118251635, compound

HRID 2203166Notes

Reaction equation

HRID 2203166 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]2.[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][N:25]=[CH:24]2)=[O:20]>>[CH3:17][O:18][C:19]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[N:26]([CH2:11][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]3[C:8]=1[N:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:6]=[CH:5]3)[N:25]=[CH:24]2)=[O:20]

Participants

3

Reactant 2

HCID 22260640Methyl 1H-indazole-5-carboxylateHCID 118251640(5-Bromo-1-isobutyl-1H-indazole-7-yl)-methanol

Product 1

HCID 118251635HCID 118251635, compoundYield 65%

Procedure

Compound 26 was prepared following general method 3A, using compound 18 as a starting material and 1H-indazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 65%.

Sources & evidence

ORD record
ord-4ef6435faf0c47b5a4b2c58a6cbe39b0
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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