Methyl 1H-indazole-5-carboxylate → HCID 118251645, compound

HRID 2203169Notes

Reaction equation

HRID 2203169 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11]O)[CH:10]=1)[N:7]([CH:13]([CH3:15])[CH3:14])[N:6]=[CH:5]2.[CH3:16][O:17][C:18]([C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][N:24]=[CH:23]2)=[O:19]>>[CH3:16][O:17][C:18]([C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[N:25]([CH2:11][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]3[C:8]=1[N:7]([CH:13]([CH3:15])[CH3:14])[N:6]=[CH:5]3)[N:24]=[CH:23]2)=[O:19]

Participants

3

Reactant 2

HCID 22260640Methyl 1H-indazole-5-carboxylateHCID 118251616HCID 118251616, compound

Product 1

HCID 118251645HCID 118251645, compoundYield 30%

Procedure

Compound 30 was prepared following general method 3A, using compound 22 as a starting material and 1H-indazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 30%.

Sources & evidence

ORD record
ord-5ce2ee5d9f7a4e93b5a20ad84ab5a8bc
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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